Volume 11 Issue 3
Jun.  2018
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Article Contents
GUO Zhen-zhen, TANG Yu-guo, MENG Fan-yu, LI Li, YANG Da-wei. Advances in preparation and biomedical applications of fluorescent carbon quantum dots[J]. Chinese Optics, 2018, 11(3): 431-443. doi: 10.3788/CO.20181103.0431
Citation: GUO Zhen-zhen, TANG Yu-guo, MENG Fan-yu, LI Li, YANG Da-wei. Advances in preparation and biomedical applications of fluorescent carbon quantum dots[J]. Chinese Optics, 2018, 11(3): 431-443. doi: 10.3788/CO.20181103.0431

Advances in preparation and biomedical applications of fluorescent carbon quantum dots

doi: 10.3788/CO.20181103.0431

National Natural Science Foundation of China 81771929

More Information
  • Corresponding author: YANG Da-wei, E-mail:yangdw@sibet.ac.cn
  • Received Date: 24 Jan 2018
  • Rev Recd Date: 13 Feb 2018
  • Publish Date: 01 Jun 2018
  • Carbon quantum dots are a class of nanomaterials with excellent fluorescence properties and high biocompatibility. They are widely used in many fields and are currently hot research materials. In this paper, different methods for the synthesis of carbon quantum dots, as well as recent advances in the performance of carbon quantum dots such as fluorescence, chemiluminescence, electrochemiluminescence, peroxidase-like activity, and toxicity, are described. Moreover, an overview of carbon quantum dots in biomedical applications such as biosensing, bioimaging, and drug delivery is also provided.


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  • [1]
    BAUGHMAN R H, ZAKHIDOV A A, DE HEER W A. Carbon nanotubes——the route toward applications[J]. Science, 2002, 297(5582):787-792. doi: 10.1126/science.1060928
    MENG F Y, TANG C H, WANG B D, et al.. Peptide and carbon nanotubes assisted detection of apoptosis by square wave voltammetry[J]. Electrochim Acta, 2016, 199:142-146. doi: 10.1016/j.electacta.2016.03.149
    HAN K, MIAO P, TONG H, et al.. Preparation of silver nanoparticles/graphene nanosheets as a catalyst for electrochemical oxidation of methanol[J]. Applied Physics Letters, 2014, 104(5):053101. doi: 10.1063/1.4863662
    JUNG S, LEE J, CHOI Y, et al.. Improved interface control for high-performance graphene-based organic solar cells[J]. 2D Materials, 2017, 4(4):045004. doi: 10.1088/2053-1583/aa823b
    LI X X, MIAO P, NING L M, et al.. Study of the interaction between graphene oxide and surface-confined biomolecules to develop new kind of biosensors[J]. Current Nanoscience, 2014, 10(6):801-806. doi: 10.2174/1573413710666140714171448
    SAVIN A V, KIVSHAR Y S. Transport of fullerene molecules along graphene nanoribbons[J]. Scientific Reports, 2012, 2:1012. doi: 10.1038/srep01012
    CIRO J, MESA S, MONTOYA J F, et al.. Simultaneous top and bottom perovskite interface engineering by fullerene surface modification of titanium dioxide as electron transport layer[J]. ACS Applied Materials & Interfaces, 2017, 9(35):29654-29659. http://cn.bing.com/academic/profile?id=2258b53859ecdb3f2099e59a78a4b974&encoded=0&v=paper_preview&mkt=zh-cn
    ARAMESH M, FOX K, LAU D W, et al.. Multifunctional three-dimensional nanodiamond-nanoporous alumina nanoarchitectures[J]. Carbon, 2014, 75:452-464. doi: 10.1016/j.carbon.2014.04.025
    WU K H, LIU Y, LUO J, et al.. The coulombic nature of active nitrogen sites in N-doped nanodiamond revealed in situ by ionic surfactants[J]. ACS Catalysis, 2017:7(5):3295-3300. doi: 10.1021/acscatal.7b00579
    MIAO P, HAN K, TANG Y G, et al.. Recent advances in carbon nanodots:synthesis, properties and biomedical applications[J]. Nanoscale, 2015, 7(5):1586-1595. doi: 10.1039/C4NR05712K
    ZHANG Z, ZHANG J, CHEN N, et al.. Graphene quantum dots:an emerging material for energy-related applications and beyond[J]. Energy & Environmental Science, 2012, 5(10):8869-8890. http://cn.bing.com/academic/profile?id=a879f95ce80e62bdef68bdf5c7b3896b&encoded=0&v=paper_preview&mkt=zh-cn
    GUPTA V, CHAUDHARY N, SRIVASTAVA R, et al.. Luminscent graphene quantum dots for organic photovoltaic devices[J]. Journal of the American Chemical Society, 2011, 133(26):9960-9963. doi: 10.1021/ja2036749
    YU P, WEN X, TOH Y R, et al.. Temperature-dependent fluorescence in carbon dots[J]. The Journal of Physical Chemistry C, 2012, 116(48):25552-25557. doi: 10.1021/jp307308z
    LIU H, YE T, MAO C. Fluorescent carbon nanoparticles derived from candle soot[J]. Angewandte Chemie International Edition, 2007, 46(34):6473-6475. doi: 10.1002/(ISSN)1521-3773
    LI Y, HU Y, ZHAO Y, et al.. An electrochemical avenue to green-luminescent graphene quantum dots as potential electron-acceptors for photovoltaics[J]. Advanced Materials, 2011, 23(6):776-780. doi: 10.1002/adma.201003819
    袁曦, 郑金桔, 李海波, 等.Mn掺杂ZnSe量子点变温发光性质研究[J].中国光学, 2015, 8(5):806-813. http://www.chineseoptics.net.cn/CN/abstract/abstract9349.shtml

    YUAN X, ZHENG J J, LI H B, et al.. Temperature-dependent photoluminescence properties of Mn-doped ZnSe quantum dots[J]. Chinese Optics, 2015, 8(5):806-813.(in Chinese) http://www.chineseoptics.net.cn/CN/abstract/abstract9349.shtml
    LIU Y, ZHAO Y, ZHANG Y. One-step green synthesized fluorescent carbon nanodots from bamboo leaves for copper(Ⅱ) ion detection[J]. Sensors and Actuators B:Chemical, 2014, 196:647-652. doi: 10.1016/j.snb.2014.02.053
    KRISHNA A S, NAIR P A, RADHAKUMARY C, et al.. Carbon dot based non enzymatic approach for the detection and estimation of glucose in blood serum[J]. Materials Research Express, 2016, 3(5):055001. doi: 10.1088/2053-1591/3/5/055001
    李晓峰, 周明, 张严, 等.氮掺杂碳量子点的合成、表征及其在细胞成像中的应用[J].材料科学与工程学报, 2015, 33(1):41-45+121. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=clkxygc201501010

    LI X F, ZHOU M, ZHANG Y, et al.. Synthesis, characterization and cell imaging application of nitrogen-doped carbon quantum dots[J]. Journal of Materials Science and Engineering, 2015, 33(1):41-45+121.(in Chinese) http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=clkxygc201501010
    CAO L, WANG X, MEZIANI M J, et al.. Carbon dots for multiphoton bioimaging[J]. Journal of the American Chemical Society, 2007, 129(37):11318-11319. doi: 10.1021/ja073527l
    SHI L, LI L, LI X, et al.. Excitation-independent yellow-fluorescent nitrogen-doped carbon nanodots for biological imaging and paper-based sensing[J]. Sensors and Actuators B:Chemical, 2017, 251:234-241. doi: 10.1016/j.snb.2017.05.065
    CHANDRA S, DAS P, BAG S, et al.. Synthesis, functionalization and bioimaging applications of highly fluorescent carbon nanoparticles[J]. Nanoscale, 2011, 3(4):1533-1540. doi: 10.1039/c0nr00735h
    DING H, DU F, LIU P, et al.. DNA-carbon dots function as fluorescent vehicles for drug delivery[J]. ACS Applied Materials & Interfaces, 2015, 7(12):6889-6897. http://cn.bing.com/academic/profile?id=72916e880fc49ebacfacf7ebf3865ee4&encoded=0&v=paper_preview&mkt=zh-cn
    MING H, MA Z, LIU Y, et al.. Large scale electrochemical synthesis of high quality carbon nanodots and their photocatalytic property[J]. Dalton Transactions, 2012, 41(31):9526-9531. doi: 10.1039/c2dt30985h
    MIAO P, TANG Y G, WANG B D, et al.. Nuclease assisted target recycling and spherical nucleic acids gold nanoparticles recruitment for ultrasensitive detection of microRNA[J]. Electrochim Acta, 2016, 190:396-401. doi: 10.1016/j.electacta.2016.01.034
    MENG F Y, MIAO P, WANG B D, et al.; Identification of glutathione by voltammetric analysis with rolling circle amplification[J]. Analytica Chimica Acta, 2016, 943:58-63. doi: 10.1016/j.aca.2016.09.035
    LI Y R, CHEN X F, WANG B D, et al.. DNA tetrahedron and star trigon nanostructures for target recycling detection of nucleic acid[J]. Analyst, 2016, 141(11):3239-3241. doi: 10.1039/C6AN00762G
    MIAO P, TANG Y G, WANG L. DNA Modified Fe3O4@Au magnetic nanoparticles as selective probes for simultaneous detection of heavy metal ions[J]. ACS Applied Materials & Interfaces, 2017, 9(4):3940-3947.
    MIAO P, YANG D W, CHEN X F, et al.. Voltammetric determination of tumor necrosis factor-alpha based on the use of an aptamer and magnetic nanoparticles loaded with gold nanoparticles[J]. Microchimica Acta, 2017, 184(10):3901-3907. doi: 10.1007/s00604-017-2419-5
    LIU T, YIN J A, WANG Y H, et al.. Construction of a specific binding peptide based electrochemical approach for sensitive detection of Zn2+[J]. Journal of Electroanalytical Chemistry, 2016, 783:304-307. doi: 10.1016/j.jelechem.2016.11.006
    李腾飞, 李昳玮, 肖璐, 等.荧光可调控的碳量子点的电化学制备及性质研究[J].化学学报, 2014, 72:227-232. doi: 10.3866/PKU.WHXB201312161

    LI T F, LI Y W, XIAO L, et al.. Electrochemical preparation of color-tunable fluorescent carbon quantum dots[J]. Acta Chimica Sinica, 2014, 72:227-232.(in Chinese) doi: 10.3866/PKU.WHXB201312161
    MIAO P, WANG B D, YU Z Q, et al.. Ultrasensitive electrochemical detection of microRNA with star trigon structure and endonuclease mediated signal amplification[J]. Biosensors and Bioelectronics, 2015, 63:365-370. doi: 10.1016/j.bios.2014.07.075
    ZHOU J, BOOKER C, LI R, et al.. An electrochemical avenue to blue luminescent nanocrystals from multiwalled carbon nanotubes(MWCNTs)[J]. Journal of the American Chemical Society, 2007, 129(4):744-745. doi: 10.1021/ja0669070
    BAO L, ZHANG Z L, TIAN Z Q, et al.. Electrochemical tuning of luminescent carbon nanodots:from preparation to luminescence mechanism[J]. Advanced Materials, 2011, 23(48):5801-5806. doi: 10.1002/adma.v23.48
    SHINDE D B, PILLAI V K. Electrochemical preparation of luminescent graphene quantum dots from multiwalled carbon nanotubes[J]. Chemistry-A European Journal, 2012, 18(39):12522-12528. doi: 10.1002/chem.201201043
    SUN D, BAN R, ZHANG P H, et al.. Hair fiber as a precursor for synthesizing of sulfur-and nitrogen-co-doped carbon dots with tunable luminescence properties[J]. Carbon, 2013, 64:424-434. doi: 10.1016/j.carbon.2013.07.095
    QIAO Z A, WANG Y, GAO Y, et al.. Commercially activated carbon as the source for producing multicolor photoluminescent carbon dots by chemical oxidation[J]. Chemical Communications, 2010, 46(46):8812-8814. doi: 10.1039/c0cc02724c
    SUN Y P, ZHOU B, LIN Y, et al.. Quantum-sized carbon dots for bright and colorful photoluminescence[J]. Journal of the American Chemical Society, 2006, 128(24):7756-7757. doi: 10.1021/ja062677d
    HU S L, NIU K Y, SUN J, et al.. One-step synthesis of fluorescent carbon nanoparticles by laser irradiation[J]. Journal of Materials Chemistry, 2009, 19(4):484-488. doi: 10.1039/B812943F
    ZHU H, WANG X, LI Y, et al.. Microwave synthesis of fluorescent carbon nanoparticles with electrochemiluminescence properties[J]. Chemical Communications, 2009, (34):5118-5120. doi: 10.1039/b907612c
    ZHANG P, LI W, ZHAI X, et al.. A facile and versatile approach to biocompatible "fluorescent polymers" from polymerizable carbon nanodots[J]. Chemical Communications, 2012, 48(84):10431-10433. doi: 10.1039/c2cc35966a
    WANG Q, LIU X, ZHANG L, et al.. Microwave-assisted synthesis of carbon nanodots through an eggshell membrane and their fluorescent application[J]. Analyst, 2012, 137(22):5392-5397. doi: 10.1039/c2an36059d
    WANG F, PANG S, WANG L, et al.. One-step synthesis of highly luminescent carbon dots in noncoordinating solvents[J]. Chemistry of Materials, 2010, 22(16):4528-4530. doi: 10.1021/cm101350u
    ZHU S, MENG Q, WANG L, et al.. Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging[J]. Angewandte Chemie International Edition, 2013, 125(14):4045-4049. http://cn.bing.com/academic/profile?id=1d5f07975fecedfc2b5cb464f2935484&encoded=0&v=paper_preview&mkt=zh-cn
    LI H, HE X, LIU Y, et al.. One-step ultrasonic synthesis of water-soluble carbon nanoparticles with excellent photoluminescent properties[J]. Carbon, 2011, 49(2):605-609. doi: 10.1016/j.carbon.2010.10.004
    PARK S Y, LEE H U, PARK E S, et al.. Photoluminescent green carbon nanodots from food-waste-derived sources:large-scale synthesis, properties, and biomedical applications[J]. ACS Applied Materials & Interfaces, 2014, 6(5):3365-3370. http://cn.bing.com/academic/profile?id=455b453b10994d12e6707c136d472a3a&encoded=0&v=paper_preview&mkt=zh-cn
    DENG J, LU Q, MI N, et al.. Electrochemical synthesis of carbon nanodots directly from alcohols[J]. Chemistry-A European Journal, 2014, 20(17):4993-4999. doi: 10.1002/chem.201304869
    MIAO P, TANG Y, HAN K, et al.. Facile synthesis of carbon nanodots from ethanol and their application in ferric(Ⅲ) ion assay[J]. Journal of Materials Chemistry A, 2015, 3(29):15068-15073. doi: 10.1039/C5TA03278D
    QU S, WANG X, LU Q, et al. A biocompatible fluorescent ink based on water-soluble luminescent carbon nanodots[J]. Angewandte Chemie International Edition, 2012, 124(49):12381-12384. http://cn.bing.com/academic/profile?id=d1e58e77d2b952ef9d75e9538847d21b&encoded=0&v=paper_preview&mkt=zh-cn
    RESCH GENGER U, GRABOLLE M, CAVALIERE-JARICOT S, et al. Quantum dots versus organic dyes as fluorescent labels[J]. Nature Methods, 2008, 5(9):763-775. doi: 10.1038/nmeth.1248
    ZHAO Q L, ZHANG Z L, HUANG B H, et al. Facile preparation of low cytotoxicity fluorescent carbon nanocrystals by electrooxidation of graphite[J]. Chemical Communications, 2008, (41):5116-5118. doi: 10.1039/b812420e
    BAKER S N, BAKER G A. Luminescent carbon nanodots:emergent nanolights[J]. Angewandte Chemie International Edition, 2010, 49(38):6726-6744. doi: 10.1002/anie.200906623
    MIAO P, TANG Y G, WANG B D, et al.. Near-infrared Ag2S quantum dots-based DNA logic gate platform for miRNA diagnostics[J]. Analytical Chemistry, 2016, 88(15):7567-7573. doi: 10.1021/acs.analchem.6b01044
    YANG S T, WANG X, WANG H, et al.. Carbon dots as nontoxic and high-performance fluorescence imaging agents[J]. The Journal of Physical Chemistry C, 2009, 113(42):18110-18114. doi: 10.1021/jp9085969
    张文宇, 常青, 周雨锋, 等.一步合成硫、氮共掺杂的碳量子点及其在Fe3+检测中的应用[J].发光学报, 2016, 37(4):410-415. http://www.doc88.com/p-5806900943515.html

    ZHANG W Y, CHANG Q, ZHOU Y F, et al.. One-step synthesis of sulfur-and nitrogen-co-doped carbon quantum dots for Fe(Ⅲ) detection[J]. Chinese Journal of Luminescence, 2016, 37(4):410-415.(in Chinese) http://www.doc88.com/p-5806900943515.html
    ZHENG H, WANG Q, LONG Y, et al.. Enhancing the luminescence of carbon dots with a reduction pathway[J]. Chemical Communications, 2011, 47(38):10650-10652. doi: 10.1039/c1cc14741b
    GUO Z, GAI L, ZHOU J, et al.. Polybromopyrrole-derived nitrogen-containing polymer dots:Synthesis, optical properties, and insight into their fluorescence quenching by aromatic compounds[J]. Sensors and Actuators B:Chemical, 2016, 232:722-731. doi: 10.1016/j.snb.2016.04.047
    LIU Y, HAN S. Chemiluminescence ofnitrogen-doped carbon quantum dots for the determination of thiourea and tannic acid[J]. Food Analytical Methods, 2017, 10(10):3398-3406. doi: 10.1007/s12161-017-0911-5
    JIANG J, HE Y, LI S, et al.. Amino acids as the source for producing carbon nanodots:microwave assisted one-step synthesis, intrinsic photoluminescence property and intense chemiluminescence enhancement[J]. Chemical Communications, 2012, 48(77):9634-9636. doi: 10.1039/c2cc34612e
    WANG Z X, ZHENG C L, LI Q L, et al.. Electrochemiluminescence of a nanoAg-carbon nanodot composite and its application to detect sulfide ions[J]. Analyst, 2014, 139(7):1751-1755. doi: 10.1039/C3AN02097E
    SUN Y P, WANG X, LU F, et al.. Doped carbon nanoparticles as a new platform for highly photoluminescent dots[J]. The Journal of Physical Chemistry C, 2008, 112(47):18295-18298. doi: 10.1021/jp8076485
    MIAO P, SHEN M, NING L, et al.. Functionalization of platinum nanoparticles for electrochemical detection of nitrite[J]. Analytical and Bioanalytical Chemistry, 2011, 399(7):2407-2411. doi: 10.1007/s00216-010-4642-3
    SHI W, WANG Q, LONG Y, et al.. Carbon nanodots as peroxidase mimetics and their applications to glucose detection[J]. Chemical Communications, 2011, 47(23):6695-6697. doi: 10.1039/c1cc11943e
    RAY S, SAHA A, JANA N R, et al.. Fluorescent carbon nanoparticles:synthesis, characterization, and bioimaging application[J]. The Journal of Physical Chemistry C, 2009, 113(43):18546-18551. doi: 10.1021/jp905912n
    SONG Y, FENG D, SHI W, et al.. Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanoparticles, and carbon nanodots on live cells as well as green gram sprouts[J]. Talanta, 2013, 116:237-244. doi: 10.1016/j.talanta.2013.05.022
    MIAO P, LIU L, LI Y, et al.. A novel electrochemical method to detect mercury(Ⅱ) ions[J]. Electrochemistry Communications, 2009, 11(10):1904-1907. doi: 10.1016/j.elecom.2009.08.013
    HOU Y, LU Q, DENG J, et al.. One-pot electrochemical synthesis of functionalized fluorescent carbon dots and their selective sensing for mercury ion[J]. Analytica Chimica Acta, 2015, 866:69-74. doi: 10.1016/j.aca.2015.01.039
    YAZID S N A M, CHIN S F, PANG S C, et al.. Detection of Sn(Ⅱ) ions via quenching of the fluorescence of carbon nanodots[J]. Microchimica Acta, 2013, 180(1-2):137-143. doi: 10.1007/s00604-012-0908-0
    ZHAO L, GENG F, DI F, et al.. Polyamine-functionalized carbon nanodots:a novel chemiluminescence probe for selective detection of iron(Ⅲ) ions[J]. RSC Advances, 2014, 4(86):45768-45771. doi: 10.1039/C4RA08071H
    MIAO P, WANG B. D, YIN J, et al.. Electrochemical tracking hydrogen peroxide secretion in live cells based on autocatalytic oxidation reaction of silver nanoparticles[J]. Electrochemistry Communications, 2015, 53:37-40. doi: 10.1016/j.elecom.2015.02.007
    MENG F Y, ZHU X L, MIAO P. Study of autocatalytic oxidation reaction of silver nanoparticles and the application for nonenzymatic H2O2 assay[J]. Chemical Physics Letters, 2015, 635:213-216. doi: 10.1016/j.cplett.2015.06.068
    LIU S, YU B, ZHANG T. Nitrogen-doped carbon nanodots as a reducing agent to synthesize Ag nanoparticles for non-enzymatic hydrogen peroxide detection[J]. RSC Advances, 2014, 4(2):544-548. doi: 10.1039/C3RA44492A
    ZHOU Y, XING G, CHEN H, et al.. Carbon nanodots sensitized chemiluminescence on peroxomonosulfate-sulfite-hydrochloric acid system and its analytical applications[J]. Talanta, 2012, 99:471-477. doi: 10.1016/j.talanta.2012.06.012
    MIAO P, TANG Y G, WANG B D, et al.. An aptasensor for detection of potassium ions based on RecJ(f) exonuclease mediated signal amplification[J]. Analyst, 2014, 139(22):5695-5699. doi: 10.1039/C4AN01350F
    HAN K, LIU T, WANG Y H, et al.. Electrochemical aptasensors for detection of small molecules, macromolecules, and cells[J]. Reviews in Analytical Chemistry, 2016, 35(4):201-211. http://cn.bing.com/academic/profile?id=c289d827b2df2212071d1239ecea1645&encoded=0&v=paper_preview&mkt=zh-cn
    YANG D W, TANG Y G, GUO Z Z, et al.. Proximity aptasensor for protein detection based on an enzyme-free amplification strategy[J]. Molecular Bio. Systems, 2017, 13:1936-1939. http://cn.bing.com/academic/profile?id=2cc603ee3e16511018446dc02f88fb6c&encoded=0&v=paper_preview&mkt=zh-cn
    XU B, ZHAO C, WEI W, et al.. Aptamer carbon nanodot sandwich used for fluorescent detection of protein[J]. The Analyst, 2012, 137(23):5483-5486. doi: 10.1039/c2an36174d
    MIAO P, TANG Y G, MAO Z Q, et al.. Adamantane derivatives functionalized gold nanoparticles for colorimetric detection of MiRNA[J]. Particle & Particle Systems Characterization, 2017, 34(6). http://cn.bing.com/academic/profile?id=a58b08ca86da61156e825b51ad1170ff&encoded=0&v=paper_preview&mkt=zh-cn
    MIAO P, WANG B D, HAN K, et al.. Electrochemical impedance spectroscopy study of proteolysis using unmodified gold nanoparticles[J]. Electrochemistry Communications, 2014, 47:21-24. doi: 10.1016/j.elecom.2014.07.013
    MIAO P, LIU L, NIE Y J, et al.. An electrochemical sensing strategy for ultrasensitive detection of glutathione by using two gold electrodes and two complementary oligonucleotides[J]. Biosensors and Bioelectronics, 2009, 24(11):3347-3351. doi: 10.1016/j.bios.2009.04.041
    MIAO P, LIANG Z Q, LIU L, et al.. Fabrication of multi-functionalized gold nanoparticles and the application to electrochemical detection of nitrite[J]. Current Nanoscience, 2011, 7(3):354-358. doi: 10.2174/157341311795542345
    MIAO P, HAN K, LIN Y, et al.. Protein-gold nanoparticles interactions and its application for alkaline phosphatase assay[J]. Micro & Nano Letters, 2012, 7(9):914-917. http://cn.bing.com/academic/profile?id=0bf960336a187d6988e342914672e77c&encoded=0&v=paper_preview&mkt=zh-cn
    QADDARE S H, SALIMI A. Amplified fluorescent sensing of DNA using luminescent carbon dots and AuNPs/GO as a sensing platform:A novel coupling of FRET and DNA hybridization for homogeneous HIV-1 gene detection at femtomolar level[J]. Biosensors and Bioelectronics, 2017, 89:773-780. doi: 10.1016/j.bios.2016.10.033
    NA N, LIU T, XU S, et al.. Application of fluorescent carbon nanodots in fluorescence imaging of human serum proteins[J]. Journal of Materials Chemistry B, 2013, 1(6):787-792. doi: 10.1039/C2TB00335J
    ZHU A, LUO Z, DING C, et al.. A two-photon "turn-on" fluorescent probe based on carbon nanodots for imaging and selective biosensing of hydrogen sulfide in live cells and tissues[J]. Analyst, 2014, 139(8):1945-1952. doi: 10.1039/C3AN02086J
    HSU P C, SHIH Z Y, LEE C H, et al.. Synthesis and analytical applications of photoluminescent carbon nanodots[J]. Green Chemistry, 2012, 14(4):917-920. doi: 10.1039/c2gc16451e
    CHANDRA A, DESHPANDE S, SHINDE D B, et al.. Mitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery[J]. ACS Macro Letters, 2014, 3(10):1064-1068. doi: 10.1021/mz500479k
    SONG Y, SHI W, CHEN W, et al.. Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells[J]. Journal of Materials Chemistry, 2012, 22(25), 12568-12573. doi: 10.1039/c2jm31582c
    NANDI S, MALISHEV R, KOOTERY K P, et al.. Membrane analysis with amphiphilic carbon dots[J]. Chemical Communications, 2014, 50(71):10299-10302. doi: 10.1039/C4CC03504F
    CHOI Y, KIM S, CHOI M H, et al.. Highly biocompatible carbon nanodots for simultaneous bioimaging and targeted photodynamic therapy in vitro and in vivo[J]. Advanced Functional Materials, 2014, 24(37):5781-5789. doi: 10.1002/adfm.201400961
    WANG Q, HUANG X, LONG Y, et al.. Hollow luminescent carbon dots for drug delivery[J]. Carbon, 2013, 59:192-199. doi: 10.1016/j.carbon.2013.03.009
    HE L, WANG T, AN J, et al.. Carbon nanodots@zeolitic imidazolate framework-8 nanoparticles for simultaneous pH-responsive drug delivery and fluorescence imaging[J]. Cryst. Eng. Comm., 2014, 16(16):3259-3263. doi: 10.1039/c3ce42506a
    TANG J, KONG B, WU H, et al.. Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging[J]. Advanced Materials, 2013, 25(45):6569-6574. doi: 10.1002/adma.201303124
    WANG J, ZHANG Z, ZHA S, et al.. Carbon nanodots featuring efficient FRET for two-photon photodynamic cancer therapy with a low fs laser power density[J]. Biomaterials, 2014, 35(34):9372-9381. doi: 10.1016/j.biomaterials.2014.07.063
    GAO N, YANG W, NIE H, et al.. Turn-on theranostic fluorescent nanoprobe by electrostatic self-assembly of carbon dots with doxorubicin for targeted cancer cell imaging, in vivo hyaluronidase analysis, and targeted drug delivery[J]. Biosensors and Bioelectronics, 2017, 96:300-307. doi: 10.1016/j.bios.2017.05.019
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