Volume 11 Issue 3
Jun.  2018
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Article Contents

WANG Xiao-yun, LI Bo, CHEN Li, LI Di, QU Song-nan, LI Zhi-min. Carbon nanodots and their composites for biomedical applications[J]. Chinese Optics, 2018, 11(3): 401-419. doi: 10.3788/CO.20181103.0401
Citation: WANG Xiao-yun, LI Bo, CHEN Li, LI Di, QU Song-nan, LI Zhi-min. Carbon nanodots and their composites for biomedical applications[J]. Chinese Optics, 2018, 11(3): 401-419. doi: 10.3788/CO.20181103.0401

Carbon nanodots and their composites for biomedical applications

doi: 10.3788/CO.20181103.0401
Funds:

National Natural Science Foundation of China 51602304

the 13th Five-Year Plan for Edu- cation Department of Jilin Province JJKH20180232KJ

More Information
  • Corresponding author: LI Zhi-min, E-mail:zhimin@jlu.edu.cn
  • Received Date: 2018-01-23
  • Rev Recd Date: 2018-03-28
  • Publish Date: 2018-06-01
  • As an emerging carbon nanomaterial, carbon nanodots(CNDs) have many advantages such as low preparation cost, small size, low toxicity, high biocompatibility, good water solubility, easy modification, unique photophysical properties, and exhibit unique advantages and application prospects in the field of biomedicine. Taking advantage of the abundant surface functional groups, carbon nanodots can interact with functional theranostic agents such as targeting ligands, contrast agents in medical imaging, nucleic acids, chemical drugs, photosensitizers, and photothermal conversion reagents to form composites. Currently, bioluminescent imaging applications of carbon nanodots and their composites in biomedical theranostic fields such as medical imaging, gene therapy, chemotherapy, photothermal therapy, and photodynamic therapy are widely studied and reported. These researches are of great significance to the development of medical theranostic reagents based on carbon nanodots and their clinical advancement, and provide a novel drug system for the advancement of individualized, visualized, non-invasive, and minimally invasive diagnosis and treatment of major human diseases. This paper focuses on the design, construction and performance of carbon nanodots and their composites used in the field of theranostics. In addition, the research progress of the reported carbon nanodots based theranostic reagents in the biomedical field is discussed and summarized.
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Carbon nanodots and their composites for biomedical applications

doi: 10.3788/CO.20181103.0401
Funds:

National Natural Science Foundation of China 51602304

the 13th Five-Year Plan for Edu- cation Department of Jilin Province JJKH20180232KJ

Abstract: As an emerging carbon nanomaterial, carbon nanodots(CNDs) have many advantages such as low preparation cost, small size, low toxicity, high biocompatibility, good water solubility, easy modification, unique photophysical properties, and exhibit unique advantages and application prospects in the field of biomedicine. Taking advantage of the abundant surface functional groups, carbon nanodots can interact with functional theranostic agents such as targeting ligands, contrast agents in medical imaging, nucleic acids, chemical drugs, photosensitizers, and photothermal conversion reagents to form composites. Currently, bioluminescent imaging applications of carbon nanodots and their composites in biomedical theranostic fields such as medical imaging, gene therapy, chemotherapy, photothermal therapy, and photodynamic therapy are widely studied and reported. These researches are of great significance to the development of medical theranostic reagents based on carbon nanodots and their clinical advancement, and provide a novel drug system for the advancement of individualized, visualized, non-invasive, and minimally invasive diagnosis and treatment of major human diseases. This paper focuses on the design, construction and performance of carbon nanodots and their composites used in the field of theranostics. In addition, the research progress of the reported carbon nanodots based theranostic reagents in the biomedical field is discussed and summarized.

WANG Xiao-yun, LI Bo, CHEN Li, LI Di, QU Song-nan, LI Zhi-min. Carbon nanodots and their composites for biomedical applications[J]. Chinese Optics, 2018, 11(3): 401-419. doi: 10.3788/CO.20181103.0401
Citation: WANG Xiao-yun, LI Bo, CHEN Li, LI Di, QU Song-nan, LI Zhi-min. Carbon nanodots and their composites for biomedical applications[J]. Chinese Optics, 2018, 11(3): 401-419. doi: 10.3788/CO.20181103.0401

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