新型多光子成像技术研究进展

石玉洁; 张广杰; 陆政元; 应亚宸; 贾荟琳; 席鹏

doi:10.3788/CO.20181103.0296

Volume 11 Issue 3

Jun. 2018

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Article Contents

Chinese Optics > 2018 > 11(3): 296-306.

SHI Yu-jie, ZHANG Guang-jie, LU Zheng-yuan, YING Ya-chen, JIA Hui-lin, XI Peng. Advances in multiphoton microscopy technologies[J]. Chinese Optics, 2018, 11(3): 296-306. doi: 10.3788/CO.20181103.0296

Citation:

SHI Yu-jie, ZHANG Guang-jie, LU Zheng-yuan, YING Ya-chen, JIA Hui-lin, XI Peng. Advances in multiphoton microscopy technologies[J]. Chinese Optics, 2018, 11(3): 296-306. doi: 10.3788/CO.20181103.0296

SHI Yu-jie, ZHANG Guang-jie, LU Zheng-yuan, YING Ya-chen, JIA Hui-lin, XI Peng. Advances in multiphoton microscopy technologies[J]. Chinese Optics, 2018, 11(3): 296-306. doi: 10.3788/CO.20181103.0296

Citation:

PDF( 4051 KB)

Advances in multiphoton microscopy technologies

doi: 10.3788/CO.20181103.0296

1.
Yuanpeng College, Peking University, Beijing 100871, China
2.
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China

Funds:

National Instrument Development Special Program No.2013YQ03065102

National Natural Science Foundation of China No.61475010

National Natural Science Foundation of China No.61729501

Ministry of Science and Technology of China, Key Research and Development Projects No.2013YQ03065102

More Information

Corresponding author: ZHANG Guang-jie, E-mail:jiezgm@126.com
Received Date: 26 Feb 2018
Rev Recd Date: 28 Mar 2018
Publish Date: 01 Jun 2018

Abstract

Abstract

Compared with traditional optical imaging techniques, the fast-developing multiphoton microscopy technologies possess multiple advantages, such as deep penetration, low tissue photo-damaging, high signal-to-noise ratio, and excellent optical sectioning ability. Therefore, they have been widely applied in tissue-level microscopy in vivo for brains, tumors and embryos. This article reviews the recent development of new multiphoton microscopy technologies, including miniaturized two-photon microscopy, two-photon endoscopy, and three-photon microscopy. The review briefly illustrates their principles and characteristics, introduces the latest progresses in these areas, summarizes their main applications in basic research and clinical diagnosis, and discusses their potential application and development in the future. With the advances in laser devices and optical detectors, multiphoton microscopy will become an important tool for biomedical research with broad applications.
- multiphoton microscopy,
- miniature two-photon microscopy,
- two-photon endoscopy,
- three-photon microscopy

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References(41)

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