多光子皮肤成像技术及其应用

应亚宸; 张广杰; 贾荟琳; 陆政元; 石玉洁; 席鹏

doi:10.3788/CO.20191201.0104

Volume 12 Issue 1

Feb. 2019

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Article Contents

Chinese Optics > 2019 > 12(1): 104-111.

YING Ya-chen, ZHANG Guang-jie, JIA Hui-lin, LU Zheng-yuan, SHI Yu-jie, XI Peng. Multi-photon skin tissue imaging technology and its applications[J]. Chinese Optics, 2019, 12(1): 104-111. doi: 10.3788/CO.20191201.0104

Citation:

YING Ya-chen, ZHANG Guang-jie, JIA Hui-lin, LU Zheng-yuan, SHI Yu-jie, XI Peng. Multi-photon skin tissue imaging technology and its applications[J]. Chinese Optics, 2019, 12(1): 104-111. doi: 10.3788/CO.20191201.0104

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Multi-photon skin tissue imaging technology and its applications

doi: 10.3788/CO.20191201.0104

1.
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
2.
Yuanpeng College, Peking University, Beijing 100871, China

Funds:

National Instrument Development Special Program 2013YQ03065102

National Natural Science Foundation of China 61475010

National Natural Science Foundation of China 61729501

Ministry of Science and Technology of China, Key Research and Development Projects 2013YQ03065102

More Information

Corresponding author: ZHANG Guang-jie. E-mail:jiezgm@126.com
Received Date: 26 Feb 2018
Rev Recd Date: 28 Mar 2018
Publish Date: 01 Feb 2019

Abstract

Abstract

Multi-photon imaging is a new technique for optical imaging with inherent optical sectioning abilities and a high signal-to-noise ratio. Multi-photon microscopy has applications in dermatological imaging for its non-invasive and in situ imaging capability. As such, it has been applied commercially. In this paper, we first introduce the core technologies of multiphoton microscopy including two-photon auto-fluorescence imaging, second-harmonic generation(SHG), fluorescence life time imaging(FLIM) and coherent anti-Stokes Raman scattering(CARS). We then introduce its application on skin imaging analysis. Finally, we analyze the advantages and the possible future development of this technology.
- skin tissue imaging,
- multi-photon fluorescence imaging,
- fluorescence life time imaging,
- coherent anti-stokes raman scattering,
- skin aging detection

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References(21)

References

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