Volume 6 Issue 5
Oct.  2013
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WANG Ying-shuai, ZHOU Ying, WANG Jun-nan, SHAO Dan, SUN Yun-lu, LI Jing, DONG Wen-fei. Controlled synthesis and cell imaging of gold nanorod-silica core-shell nanoparticles[J]. Chinese Optics, 2013, 6(5): 743-749. doi: 10.3788/CO.20130605.0743
Citation: WANG Ying-shuai, ZHOU Ying, WANG Jun-nan, SHAO Dan, SUN Yun-lu, LI Jing, DONG Wen-fei. Controlled synthesis and cell imaging of gold nanorod-silica core-shell nanoparticles[J]. Chinese Optics, 2013, 6(5): 743-749. doi: 10.3788/CO.20130605.0743

Controlled synthesis and cell imaging of gold nanorod-silica core-shell nanoparticles

  • Received Date: 12 Jul 2013
  • Rev Recd Date: 17 Sep 2013
  • Publish Date: 10 Oct 2013
  • The template method and sol-gel technique were used for the preparation of gold nanorod-silica core-shell (GNR@SiO2) nanocomposites. The controllable synthesis, spectroscopic properties, cytotoxicity and cell imaging of these nanocomposites were discussed by using UV-Vis spectrophotometry, transmission electron microscopy, confocal microscopy and other characterized measurements. The results show that, by control of the reaction time, the thickness of silica shell can be facilely tuned in the regime of 20-30 nm; the colloidal stability of gold nanorods has been greatly improved, and their cell cytotoxicities are significantly decreased due to the presence of the silica shell. In addition, fluorescent probes can be easily attached on the silica shell by post chemical reactions. As formed fluorescent core-shell nanocomposites can be easily captured by cells through endocytosis pathway, which is useful for the optical imaging. Therefore, these nanoparticle composites have a great potential in fields of biosensors, cell imaging and photothermal therapy.

     

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