Volume 6 Issue 5
Oct.  2013
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ZHOU Ming-hui, LIAO Chun-yan, REN Zhao-yu, FAN Hai-ming, BAI Jin-tao. Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications[J]. Chinese Optics, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
Citation: ZHOU Ming-hui, LIAO Chun-yan, REN Zhao-yu, FAN Hai-ming, BAI Jin-tao. Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications[J]. Chinese Optics, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633

Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications

  • Received Date: 12 Sep 2013
  • Rev Recd Date: 13 Oct 2013
  • Publish Date: 10 Oct 2013
  • The bioimaging technology based on the Surface-enhanced Raman Spectroscopy(SERS) has emerged as a potential alternative due to its narrow bandwidth, weak background interference, high stability of label agent and specificity. Raman imaging technique can not only analyze a single point of the sample, but also offer an integral description of ingredient, distribution and variation for a large scale selected region. This paper introduces the principle of surface enhanced Raman scattering and its enhancement mechanism. Then, it reviews the recent development of SERS based bioimaging where both non-labeled and labelled SERS imaging techniques are included, and describes its applications to the biomedicine. Finally, it discusses some problems existed in the current technology and points out the future developing trends of the SERS-based bioimaging.

     

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