Volume 13 Issue 5
Sep.  2020
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LU Dong-xiao, FANG Wen-hui, LI Yu-yao, LI Jin-hua, WANG Xiao-jun. Optical coherence tomography: principles and recent developments[J]. Chinese Optics, 2020, 13(5): 919-935. doi: 10.37188/CO.2020-0037
Citation: LU Dong-xiao, FANG Wen-hui, LI Yu-yao, LI Jin-hua, WANG Xiao-jun. Optical coherence tomography: principles and recent developments[J]. Chinese Optics, 2020, 13(5): 919-935. doi: 10.37188/CO.2020-0037

Optical coherence tomography: principles and recent developments

Funds:  Supported by the“111” Project of China (No. D17017); National Natural Science Foundation of China (No. 21703017, No. 11604024); Developing Project of Science and Technology of Jilin Province (No. 20180519017JH, No. 20190201181JC); International Science and Technology Cooperation Project of Jilin Province (No. 20190701029GH); Project of Education Department of Jilin Province (No. JJKH20190551KJ, No. JJKH20200730KJ); China Postdoctoral Science Foundation (No. 2019M651181); Youth Fund and Technology Innovation Fund of Changchun University of Science and Technology (No. XQNJJ-2018-03, No. XJJLG-2018-01); Open Foundation of Key Laboratory for UV-Emitting Materials and Technology of Ministry of Education, Northeast Normal University (No. 130028908)
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  • Corresponding author: xwang@georgiasouthern.edu
  • Received Date: 13 Mar 2020
  • Rev Recd Date: 20 Apr 2020
  • Available Online: 01 Sep 2020
  • Publish Date: 01 Oct 2020
  • Optical Coherence Tomography (OCT) is a new imaging technique that uses interference in low coherent light by measuring the delay and magnitude of backscattered or reflected signals from the sample. OCT technology can provide real-time structural information with one-dimensional depth and two- and three-dimensional tomography at micron-scale resolution. Besides its high spatial resolution, OCT imaging is beneficial for its non-contact and non-invasive methodology. The system is also easy to operate and relatively portable. OCT technology is mainly applied in the biomedical imaging field for diagnoses, making up for the shortcomings of the low penetration depth in confocal microscopes and the low resolution in ultrasonic imaging. At present, OCT technology has been used as the clinical standard for the diagnosis of retinal diseases, and the combination of OCT technology and endoscope technology has become an important tool for the clinical diagnosis of cardiovascular and gastrointestinal diseases. It also provides references for early cancer diagnosis, surgical guidance and postoperative rehabilitation of musculoskeletal diseases. To broaden the application of OCT technology and improve its medical detection capabilities, researchers are committed to increasing the penetration depth of OCT imaging in biological tissue, improving the system's resolution and signal-to-noise ratio, and optimizing its overall performance. This review introduces the principle and classification of OCT systems, their applications and their recent progress in various biomedical fields.

     

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