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表面增强拉曼光谱生物成像技术及其应用

周明辉 廖春艳 任兆玉 樊海明 白晋涛

周明辉, 廖春艳, 任兆玉, 樊海明, 白晋涛. 表面增强拉曼光谱生物成像技术及其应用[J]. 中国光学, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
引用本文: 周明辉, 廖春艳, 任兆玉, 樊海明, 白晋涛. 表面增强拉曼光谱生物成像技术及其应用[J]. 中国光学, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
ZHOU Ming-hui, LIAO Chun-yan, REN Zhao-yu, FAN Hai-ming, BAI Jin-tao. Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications[J]. Chinese Optics, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
Citation: ZHOU Ming-hui, LIAO Chun-yan, REN Zhao-yu, FAN Hai-ming, BAI Jin-tao. Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications[J]. Chinese Optics, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633

表面增强拉曼光谱生物成像技术及其应用

doi: 10.3788/CO.20130605.0633
基金项目: 

国家自然科学基金资助项目(No.21006079);高等学校博士学科点专项科研基金资助项目(No.20126101110017)

详细信息
    作者简介:

    周明辉(1989-),男,内蒙古赤峰人,硕士研究生,2008年于中国地质大学(武汉)获得学士学位,主要从事表面增强拉曼散射生物成像方面的研究。E-mail:zhouminghui89@sina.com

    通讯作者: 樊海明
  • 中图分类号: O657.37;Q-334

Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications

  • 摘要: 基于表面增强拉曼光谱的成像分析方法具有频带窄,水溶液背景弱,稳定性好,高特异性等优势已成为生物成像领域的优良选择。拉曼成像技术拓展了拉曼光谱的应用范围,使其不再只是检测单点化学成分的手段,而进一步用于对评价区域内化学物质成分、分布及变化进行整体统计和描述。本文探讨了表面增强拉曼散射的原理及增强机制,介绍了基于表面增强拉曼光谱的拉曼成像技术,并对其在无标记成像及带标记成像中的细胞成像、活体成像,特别是其在生物医学方面的应用进行了详细论述,最后讨论了表面增强拉曼光谱生物成像技术存在的问题,展望了该项技术的研究和应用前景。
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  • 收稿日期:  2013-09-12
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表面增强拉曼光谱生物成像技术及其应用

doi: 10.3788/CO.20130605.0633
    基金项目:

    国家自然科学基金资助项目(No.21006079);高等学校博士学科点专项科研基金资助项目(No.20126101110017)

    作者简介:

    周明辉(1989-),男,内蒙古赤峰人,硕士研究生,2008年于中国地质大学(武汉)获得学士学位,主要从事表面增强拉曼散射生物成像方面的研究。E-mail:zhouminghui89@sina.com

    通讯作者: 樊海明
  • 中图分类号: O657.37;Q-334

摘要: 基于表面增强拉曼光谱的成像分析方法具有频带窄,水溶液背景弱,稳定性好,高特异性等优势已成为生物成像领域的优良选择。拉曼成像技术拓展了拉曼光谱的应用范围,使其不再只是检测单点化学成分的手段,而进一步用于对评价区域内化学物质成分、分布及变化进行整体统计和描述。本文探讨了表面增强拉曼散射的原理及增强机制,介绍了基于表面增强拉曼光谱的拉曼成像技术,并对其在无标记成像及带标记成像中的细胞成像、活体成像,特别是其在生物医学方面的应用进行了详细论述,最后讨论了表面增强拉曼光谱生物成像技术存在的问题,展望了该项技术的研究和应用前景。

English Abstract

周明辉, 廖春艳, 任兆玉, 樊海明, 白晋涛. 表面增强拉曼光谱生物成像技术及其应用[J]. 中国光学, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
引用本文: 周明辉, 廖春艳, 任兆玉, 樊海明, 白晋涛. 表面增强拉曼光谱生物成像技术及其应用[J]. 中国光学, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
ZHOU Ming-hui, LIAO Chun-yan, REN Zhao-yu, FAN Hai-ming, BAI Jin-tao. Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications[J]. Chinese Optics, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
Citation: ZHOU Ming-hui, LIAO Chun-yan, REN Zhao-yu, FAN Hai-ming, BAI Jin-tao. Bioimaging technologies based on surface-enhanced Raman spectroscopy and their applications[J]. Chinese Optics, 2013, 6(5): 633-642. doi: 10.3788/CO.20130605.0633
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