Abstract: An optical system of portable fundus angiography in dual-bands is designed based on the Gullstrand-Le Grand eye model. By considering the human vision system and applying the coaxial illumination, the apparatus with 2 mega pixels in all fields of view is designed, which can be used in Fundus Fluorescein Angiography(FFA) and Indocyanine Green Angiography(ICGA) under the wave bands of 525 nm and 826 nm. An annular diaphragm, a hollow mirror and a coaxial illumination are adopted in the illuminating system to avoid the stray light caused by the reflection of the corneal surface. Furthermore, two aspheric surfaces are involved in order to simplify the photographic system. The result shows that with a larger accommodation, this system can adapts to human eyes from -10 m-1 to +8 m-1. With the field of view of 30, the resolution of the eyeground over 108 lp/mm, and the distortion value less than 10% the system can satisfy the requirements as a portable dual-band imaging instrument.