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Longitudinal chromatic aberration compensation method for dual-wavelength retinal imaging adaptive optics systems

ZHU Qin-yu HAN Guo-qing PENG Jian-tao RAO Qi-long SHEN Yi-li CHEN Mei-rui SUN Hui-juan MAO Hong-min XU Guo-ding CAO Zhao-liang XUAN Li

朱沁雨, 韩国庆, 彭建涛, 饶启龙, 沈毅力, 陈梅蕊, 孙会娟, 毛红敏, 徐国定, 曹召良, 宣丽. 双波长视网膜成像自适应光学系统的轴向色差补偿方法[J]. 中国光学, 2022, 15(1): 79-89. doi: 10.37188/CO.EN.2021-0009
引用本文: 朱沁雨, 韩国庆, 彭建涛, 饶启龙, 沈毅力, 陈梅蕊, 孙会娟, 毛红敏, 徐国定, 曹召良, 宣丽. 双波长视网膜成像自适应光学系统的轴向色差补偿方法[J]. 中国光学, 2022, 15(1): 79-89. doi: 10.37188/CO.EN.2021-0009
ZHU Qin-yu, HAN Guo-qing, PENG Jian-tao, RAO Qi-long, SHEN Yi-li, CHEN Mei-rui, SUN Hui-juan, MAO Hong-min, XU Guo-ding, CAO Zhao-liang, XUAN Li. Longitudinal chromatic aberration compensation method for dual-wavelength retinal imaging adaptive optics systems[J]. Chinese Optics, 2022, 15(1): 79-89. doi: 10.37188/CO.EN.2021-0009
Citation: ZHU Qin-yu, HAN Guo-qing, PENG Jian-tao, RAO Qi-long, SHEN Yi-li, CHEN Mei-rui, SUN Hui-juan, MAO Hong-min, XU Guo-ding, CAO Zhao-liang, XUAN Li. Longitudinal chromatic aberration compensation method for dual-wavelength retinal imaging adaptive optics systems[J]. Chinese Optics, 2022, 15(1): 79-89. doi: 10.37188/CO.EN.2021-0009

双波长视网膜成像自适应光学系统的轴向色差补偿方法

doi: 10.37188/CO.EN.2021-0009
详细信息
  • 中图分类号: O439

Longitudinal chromatic aberration compensation method for dual-wavelength retinal imaging adaptive optics systems

Funds: Supported by China Jiangsu Key Disciplines of the Thirteenth Five-Year Plan (No. 20168765); Industry-University-Institute Cooperation Foundation of the Eighth Research Institute of China Aerospace Science and Technology Corporation (No. SAST2020-025); Academic Research Projects of Beijing Union University (No. ZK70202007).
More Information
    Author Bio:

    ZHU Qin-yu (1997—), male, born in Wuxi, Jiangsu Province, master student. He received his bachelor's degree from Changshu Institute of Technology in 2019. He is mainly engaged in the research of photoelectric instruments and intelligent detection technology. E-mail: zhuqywx@163.com

    CAO Zhao-liang (1974—), male, born in Jiyuan, Henan Province, Ph.D., professor and doctoral supervisor. He received his Ph.D. from Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences in 2008. He is mainly engaged in research of liquid crystal adaptive optical system: optical design, optical experiment, theoretical analysis and simulation. E-mail: caozl@usts.edu.cn

    Corresponding author: caozl@usts.edu.cn
  • 摘要: 双波长视网膜成像自适应光学系统非常适用于视网膜微血管的高对比度和高分辨率成像。本文重点研究了双波长自适应系统的轴向色差补偿问题。首先对轴向色差进行了测量,对实测波前进行了分析,并给出任意波前轴向色差补偿法。自适应校正实验结果显示,色差补偿后,波前均方根误差减小到0.16 λ(λ=589 nm),视网膜微血管分辨率提高到6 μm。这项工作可用于视网膜成像的临床应用。
  • Figure  1.  Illustration of the optical setup for LCA measurement: two lasers are used with the wavelength of 589 nm and 808 nm

    Figure  2.  Time sequence for system control

    Figure  3.  Measured wavefronts of subject A. (a) Wavelength of 589 nm; (b) wavelength of 808 nm; (c) LCA; (d) LCA without defocus

    Figure  4.  Measured LCA for different subjects, with and without defocus at λ=589 nm

    Figure  5.  Wavefronts of LCA at different times for subject A. (a) Start; (b) 5 minutes later; (c) 1 hour later; (d) 10 hours later; (e) 15 hours later; (f) 24 hours later; (g) 30 hours later; (h) 36 hours later

    Figure  6.  Measured LCA at different times for subject A

    Figure  7.  Calculated compensation of LCA for subject A at different times while the first wavefront of Fig. 5 is chosen as the arbitrary wavefront. The mean value of LCA is 0.16 λ with the standard deviation of 0.017. (a) Start; (b) 5 minutes later; (c) 1 hour later; (d) 10 hours later; (e) 15 hours later; (f) 24 hours later; (g) 30 hours later; (h) 36 hours later

    Figure  8.  Compensation of LCA for subject A at different times. The mean value of the arbitrary wavefront is 0.158±0.011 λ.

    Figure  9.  Compensation of LCA for different subjects. The mean values of the arbitrary wavefront is 0.166±0.017 λ.

    Figure  10.  Optical layout for the retinal imaging AOS: L1-L13, Lens 1- Lens 13; PBS, polarizing beam splitter; BS, beam splitter; an 808 nm laser is used for wavefront detection, tracing and positioning the capillary; a 589 nm laser is used for high contrast imaging of the capillary; the collimated beam comes from the illumination system and is reflected into the eye, and then reflected again out from the eye by the retina; this reflected light is detected and corrected by the adaptive optics system and imaged with an imaging camera; the pupil position is observed by the pupil monitoring system and the eye is fixed with the target staring system

    Figure  11.  Experimental configuration of the AOS on an optical flat

    Figure  12.  Experiment results of adaptive correction and LCA compensation for subjects A and C. (a) Measured aberration at 808 nm for subject A; (b) wavefront of LCA for subject A; (c) image of retinal capillary without LCA compensation for subject A; (d) image of retinal capillary after LCA compensation for subject A; (e) measured aberration at 808 nm for subject C; (f) wavefront of LCA for subject C; (g) image of retinal capillary without LCA compensation for subject C; (h) image of retinal capillary after LCA compensation for subject C

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出版历程
  • 收稿日期:  2021-09-06
  • 修回日期:  2021-09-26
  • 网络出版日期:  2021-10-22
  • 刊出日期:  2022-01-19

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